Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans.
May 15. 2018
Kim KM, Wijerathne T, Hur JH, Kang UJ, Kim IH, Kweon YC, Lee AR, Jeong SJ, Lee SK, Lee YY, Sim BW, Lee JH, Baig C, Kim SU, Chang KT, Lee KP, Park CY
This study identifies a previously unknown SOCE mechanism in C. elegans and suggests that, while the STIM-Orai interaction is conserved between invertebrates and mammals, the gating mechanism for Orai channels differs considerably.
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
Oct. 11, 2018
Eun Kyung Song, Jimin Jeon, Dong Gil Jang, Ha Eun Kim, Hyo Jung Sim, Keun Yeong Kwon, Sofia Medina-Ruiz, Hyun-Jun Jang, Ah Reum Lee, Jun Gi Rho, Hyun-Shik Lee, Seok Jung Kim, Chan Young Park, Kyungjae Myung, Wook Kim, Taejoon Kwon, Siyoung Yang, Tae Joo Park
This study identifies a target to modulate integrin signaling, which could have potential therapeutic effects for OA
Molecular Interactions of Autophagy with the Immune System and Cancer.
Aug. 3 2017
Jin Y, Hong Y, Park CY*, Hong Y*
We summarize the current understanding of autophagy and its regulation in cancer.
A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.
This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC.
Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.
Jun 8 2015
Our results reveal a previously unrecognized functional flexibility in the STIM protein family by which alternative splicing creates negative and positive regulators of SOCE to shape the amplitude and dynamics of Ca(2+) signals.
Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays
Amir Masoud Sadaghiani, Sang Min Lee, Justin I. Odegaard, Dennis B. Leveson-Gower, Olivia M. McPherson, Paul Novick, Mi Ri Kim, Angela N. Koehler, Robert Negrin, Ricardo E. Dolmetsch and Chan Young Park,
Sang-Mun Chi, Young-Kyo Seo, Young-Kyu Park, Sora Yoon, Chan Young Park, Yong Sung Kim, Seon-Young Kim and Dougu Nam (2014) REGNET: mining context-specific human transcription networks using composite genomic information
Park CY, Shcheglovitov A, Dolmetsch R. (2010) The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels. Science. 330:101-5
*This paper has been introduced in several journals in special introductory articles. Science (perspectives), Science signaling (Editor’s Choice), Faculty of 1000
Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. (2009) Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 139:380-92
Mullins FM, Park CY, Dolmetsch RE, Lewis RS. (2009) STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Proc Natl Acad Sci U S A.;106:15495-500.
(Direct submission; co-first)
* This paper has been highlighted in “Faculty of 1000”
Chan Young Park, P.J. Hoover, F. Mullins, P. Bachhawat, E.D. Covington S. Raunser,T. Walz, C.K. Garcia, R.E. Dolmetsch and R.S. Lewis (Co-corresponding authors) (2009) STIM1 Clusters and Activates CRAC channels via Direct Binding of a Cytosolic Domain to Orai1. Cell. 136, 876-890
* This paper has been introduced in several journals in special introductory articles. Cell (Comment in), Faculty of 1000 ** Chosen as fast breaking paper in 2010, ScienceWatch (Thomson Reuters)
C.Y. Park and R.E. Dolmetsch, Cell signaling. The double life of a transcription factor takes it outside the nucleus. Science (2006) 314, 64-5